Dosimetric results showed that all tissues received almost insignificant absorbed doses in comparison with bone tissues. The complex showed rapid bone uptake, while accumulation in other organs was insignificant. 177Lu-TTHMP was successfully prepared with high radiochemical purity (>99%). Results: 177Lu was prepared with 2.6-3 GBq/mg specific activity and radionuclide purity of 99.98%. Preliminary dose evaluation was investigated based on biodistribution data in rats. The complex was injected to wild-type rats and biodistribution was studied for 7 days. Radiochemical purity of the 177Lu-TTHMP complex was determined using instant thin-layer chromatography (ITLC) and high performance liquid chromatography (HPLC) methods. Methods: TTHMP was synthesized and characterized, using spectroscopic methods. In this study, production, quality control, biodistribution, and dose evaluation of 177Lu-TTHMP have been investigated and compared with the previously reported data. Although 177Lutriethylene tetramine hexa methylene phosphonic acid (abbreviated as 177Lu- TTHMP), as an agent for bone pain palliation, has been evaluated in previous studies, there are large discrepancies between the obtained results. The obtained retention values indicated that the compound under investigation was not suitable for the purpose of high specific activity radioisotope production.Objective(s): Recently, bone-avid radiopharmaceuticals have been shown to have potential benefits for the treatment of widespread bone metastases. The retention values of 177Lu in three different cases were determined. Paper chromatography gave the best results when the compound was dissolved and developed in toluene. The retention depended on the type of paper and the pattern of solvent/developer. The species resulting from β-decay reaction were little affected by the type of paper chromatography, while those resulting from (n,γ) reaction were not affected at all. It was found that the organic and inorganic species were of different types and the species resulting from (n,γ) differed from those resulting from β-decay.

Paper chromatography as well as thin layer chromatography, using different patterns of solvents and developers, are discussed.

The behavior of recoiled radionuclides 169Yb, 175Yb, and 177Lu resulting from the reactions 168Yb(n,γ) 169Yb, 174Yb(n,γ) 175Yb, and 176Yb(n,γ) 177Yb→ 177Lu, respectively, in the organometallic Tris(2,2,6,6-tetramethyle-3,5-heptanedionato)Yb(III) compound was investigated.

Iaea tecdoc 1340